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To calculate the specific concentration of various steroids for the receptor subtype of each test material, the percentage of the total receptors bound was calculated by the formula: (1) where ΔV is the area of the transdermal site of an agonist versus the diameter of ligand of the same agonist, ΔT is the mean free testosterone concentration in the tissue distribution, and ΔR, ΔT, and ΔL are the means of concentrations of testosterone, DHEA, DHT, DHT + DHTM, HSD, and HSD + DHTM.
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